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Volume 16, Issue 2 (Summer-Fall 2022)
IJOP 2022, 16(2): 201-210 |
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Vahedi. G N, Asgari A, Dehghan G. Detection of the O6-Carboxymethylguanine DNA Adduct in Colorectal Cancer Using a Graphene Field-Effect Transistor-Based Biosensors. IJOP 2022; 16 (2) :201-210
URL: http://ijop.ir/article-1-530-en.html
URL: http://ijop.ir/article-1-530-en.html
1- Faculty of Physics, University of Tabriz, Tabriz, Iran
2- Faculty of Physics, University of Tabriz, Tabriz, Iran & Photonics Devises Research Group, Research Institute for Applied Physics and Astronomy, University of Tabriz, Tabriz, Iran & School of Electrical, Electronic, and Computer Engineering; The University of Western Australia, Crawley, WA 6009, Australia
3- Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
2- Faculty of Physics, University of Tabriz, Tabriz, Iran & Photonics Devises Research Group, Research Institute for Applied Physics and Astronomy, University of Tabriz, Tabriz, Iran & School of Electrical, Electronic, and Computer Engineering; The University of Western Australia, Crawley, WA 6009, Australia
3- Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
Abstract: (698 Views)
Efforts to understand genetic diseases and mutations in biological systems are the most important driver of research development in medical and biomolecular sciences. Rapid, sensitive, accurate, and cost-effective biomolecule analysis is particularly important in diagnosis and treatment. The discovery of graphene as a new nanomaterial with a carbon structure with a single atom thickness due to its unique electronic, mechanical, thermal, and optical properties has opened a new topic in research in various biomedical sciences and the production of biosensors for biomolecule analysis. In this research, a biosensor based on a graphene field-effect transistor (GFET) is used to detect DNA with optimal accuracy and sensitivity, which can be a basis for making DNA detection tools. In the studied structure, using non-equilibrium Green function equations and Poisson equation, we study the electron transfer in graphene field-effect transistors. Then, by examining the interaction between nucleotide bases (C, G, A, T) and O6-carboxymethylguanine related to the colorectal cancer DNA sequence to detection of mutation will be identified by GFET, and their binding energy determined.
Type of Study: Research |
Subject:
Medical Optics, Optical Microscope, Biophotonics
Received: 2023/04/4 | Revised: 2023/06/20 | Accepted: 2023/06/10 | Published: 2023/06/19
Received: 2023/04/4 | Revised: 2023/06/20 | Accepted: 2023/06/10 | Published: 2023/06/19
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