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Mr Hamed Nikbakht, Prof Hamid Latifi, Ms Tahereh Amini, Dr Mohammad Ismail Zibaii,
Volume 8, Issue 2 (International Journal of Optics and Photonics (IJOP) Vol 8, No 2, Summer-Fall 2014)
Abstract

In this paper, a tapered tip optical fiber probe sensor for localized refractive index (RI) measurements is presented. This sensor’s interaction with analytes is confined to a few micro-meters which makes it a promising candidate for in-vivo or even intra-cellular RI monitoring. This tapered tip was simply fabricated by etching optical fiber with hydrofluoric acid to a conic shape with a sub-micrometer aperture. The sensor was calibrated for RI measurement using different concentrations of NaCl in water. Limit of detection of 6.7×10-5 RIU was achieved for this low-cost sensor.
Batul Nasrabadi, Mohammad Ismail Zibaii, Seyedeh Mahshad Hosseini,
Volume 16, Issue 1 (Winter-Spring 2022)
Abstract

ta charset="UTF-8" >Optogenetics is an advanced optical tool in neuroscience research. However, light stimulation in optogenetic experiments may also affect neural function by generating heat. In this paper, the effect of increasing the temperature of the brain tissue was studied during light stimulation. The Hodgkin-Huxley model and the hippocampal pyramidal cell model have been used to investigate the effect of temperature on spike neurons. The modeling results show that irradiation of brain tissue by pulsed laser with a frequency of 40 Hz, the duty cycle of 90% and wavelength of 593 nm at a distance of 10 μm from the tip of the fiber, for 60 seconds with a power of 1 and 40 mW leads to the temperature change from 37 °C to 39 °C. The obtained results show that the laser intensity decreases to zero at a distance of 1 mm from the tip of a fiber, which is absorbed by the tissue and causes a temperature rise of 2 °C that can increase the spike rate of neurons by 16.6%.

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