Showing 1 results for Vahedi. G
Nasrin Vahedi. G, Asghar Asgari, Gholamreza Dehghan,
Volume 16, Issue 2 (Summer-Fall 2022)
Abstract
Efforts to understand genetic diseases and mutations in biological systems are the most important driver of research development in medical and biomolecular sciences. Rapid, sensitive, accurate, and cost-effective biomolecule analysis is particularly important in diagnosis and treatment. The discovery of graphene as a new nanomaterial with a carbon structure with a single atom thickness due to its unique electronic, mechanical, thermal, and optical properties has opened a new topic in research in various biomedical sciences and the production of biosensors for biomolecule analysis. In this research, a biosensor based on a graphene field-effect transistor (GFET) is used to detect DNA with optimal accuracy and sensitivity, which can be a basis for making DNA detection tools. In the studied structure, using non-equilibrium Green function equations and Poisson equation, we study the electron transfer in graphene field-effect transistors. Then, by examining the interaction between nucleotide bases (C, G, A, T) and O6-carboxymethylguanine related to the colorectal cancer DNA sequence to detection of mutation will be identified by GFET, and their binding energy determined.
